Kazuaki Matsumura Associate Professor
School of Materials Science,Materials Chemistry Area
◆Degrees
Doctor of Engineering from Kyoto University(2004)
◆Specialties
Biomaterials, Polymer science
◆Research Keywords
biomaterials, functional polymer, gel, tissue engineering, cryobiology
◆Research Interests
Functional polymeric biomaterials
The creation of functional polymers is a widely studied process for application in biomaterials and tissue engineering materials. Functional polymers have many applications with regard to biomaterials, such as hydrogels, bioabsorbable materials, and artificial bones. In this regard, not only bulky soft materials but also colloids, micelles, and even solutions can be studied as materials for controlling the functions of cells or tissues. Polyampholytes are polymers that have both positive and negative ions in 1 molecule. Our results revealed that several kinds of polyampholytes have a cryoprotective effect on cells in solution. This interesting phenomenon is a characteristic of polymers with high electron charge, especially polyampholytes. From the cryobiological viewpoint, cells are killed because of damage caused by intracellular crystallization of water during freezing. Therefore, we usually add some membrane-permeable chemicals such as dimethyl sulfoxide to cryopreserve cells. However, the phenomenon that non-membrane-penetrating polymers such as polyampholytes can reduce the damage that occurs during freezing cannot be explained on the basis of current knowledge in cryobiology. We will investigate and develop membrane-protective materials that can control cell functions by clarifying the mechanisms underlying such effects. Polyampholytes can change their conformation by controlling the polyion complex and thus exhibit various interesting physicochemical properties. We will try to develop novel functional materials by investigating the interactions between living systems and these polymers and by using the physicochemical properties of the polymers. We also perform basic and applied research on materials well-matched to living systems; this research is aimed toward the regeneration of functions in tissue engineering. In particular, we are trying to develop a novel cell culture scaffold, polymeric nano-carriers for drug delivery systems and articular cartilage by using hydrogels with high mechanical properties. The research performed in our laboratory is aimed toward the fusion of chemistry and biology through polymer chemistry and toward the development of materials that can control living systems. 備考

■Publications

◆Published Papers
Comparative Study of Protein Aggregation Arrest by Zwitterionic Polysulfobetaines: Using Contrasting Raft Agents.
Sharma N, Rajan R, Makhaik S, Matsumura K
ACS omega, 4, 7, 12186-12193, 2019/07
Effect of dual-drug-releasing micelle-hydrogel composite on wound healing in vivo in full-thickness excision wound rat model.
Patel M, Nakaji-Hirabayashi T, Matsumura K
Journal of biomedical materials research. Part A, 107, 5, 1094-1106, 2019/05
Amino-Carrageenan@ Polydopamine Microcomposites as Initiators for the Degradation of Hydrogel by near-Infrared Irradiation for Controlled Drug Release
Matsumura Kazuaki
ACS Applied Polymer Materials , 1, 2, 286-297, 2019/01
Controlling the degradation of an oxidized dextran-based hydrogel independent of the mechanical properties.
Nonsuwan P, Matsugami A, Hayashi F, Hyon SH, Matsumura K
Carbohydrate polymers, 204, 131-141, 2019/01
Micro-patterned cell orientation of cyanobacterial liquid-crystalline hydrogels.
Sornkamnerd S, Okajima MK, Matsumura K, Kaneko T
ACS applied materials & interfaces, 10, 51, 44834-44843, 2018/11
◆Misc
Cryoprotective effect of carboxylated poly-L-lysine on the nematode Caenorhabditis elegans
Masakazu Hayashi, Norio Murase, Kazuaki Matsumura
Refrigeration Science and Technology, 4517-4520, 2015/01/01
Degradation control of cellulose scaffold by Malaprade oxidation
Wichchulada Konkumnerd, Wichchulada Konkumnerd, Suong Hyu Hyon, Kazuaki Matsumura
Materials Research Society Symposium Proceedings, 1621, -, 2014/01/01
Freezing assisted protein delivery by using polymeric cryoprotectant
Sana Ahmed, Sana Ahmed, Kazuaki Matsumura
Materials Research Society Symposium Proceedings, 1622, -, 2014/01/01
To see a friend from different field is a joy
Kazuaki Matsumura
Kobunshi, 63, 39-40, 2014/01/01
Hydrogel formation from the concentrated aqueous solution of polyvinyl alcohol
Tomoyo Sakaguchi, Suong Hyu Hyon, Kazuaki Matsumura
Materials Research Society Symposium Proceedings, 1622, -, 2014/01/01
◆Books
Development and Application of Cryoprotectants (Chapter 18), In Survival Strategies in Extreme Cold and Desiccation. Eds Mari Iwaya-Inoue, Minoru Sakurai, Matsuo Uemura
Robin Rajan, Kazuaki Matsumura, Springer, 2018
Medical Application ofPolyampholytes. In Biopolymers for Medical Applications
Kazuaki Matsumura, Robin Rajan, Sana Ahmed, Minkle Jain, CRC Press, 2016
Cell and Materials Interface in Cryobiology and Cryoprotection. In Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies
Kazuaki Matsumura, Minkle Jain, Rajan Robin, CRC Press, 2015
◆Conference Activities & Talks
Degradation control of polysaccharides and the biomedical applications
Kazuaki Matsumura, Wichchulada Chimpibul, Punnida Nonsuwan
PCT-8, Bangkok, 2018/06/14
Biomedical Application of Polyampholytes
Kazuaki Matsumura
SI/SK/SM Workshop 2017, Bangkok, 2017/09/26
Development of gene delivery system by freeze concentration
松村和明、Sana Ahmed
第62回低温生物工学会, 札幌市, 2017/05/20
Degradation control of oxidized dextran hydrogel formed via Michael addition
K. Matsumura, N. Punnida
26th MRS-J, 横浜市, 2016/12/19
Tissue-engineered constructs preservation using a novel slow vitrification method with hydrophobically modified polyampholyte to inhibit ice crystallization
Kazuaki Matsumura, Manato Suzuki, Daisuke Tanaka, Suong-Hyu Hyon
10th WBC, Montreal, 2016/05/18

■Teaching Experience

Introduction of Chemistry, Polymer Chemistry II, Materials Design(E)

■Contributions to  Society

◆Academic Society Affiliations
American Chemical Society, JAPANESE SOCIETY FOR CRYOBIOLOGY AND CRYOTECHNOLOGY, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, THE JAPANESE SOCIETY FOR BIOMATERIALS, THE SOCIETY OF POLYMER SCIENCE, JAPAN, THE CHEMICAL SOCIETY OF JAPAN
◆Academic Contribution
International Workshop on Functional Polymer Science and Interface 2013 , Kazuaki Matsumura, Associate professor, JAIST , 2013/03/19 , JAIST