MATSUMURA, Kazuaki Professor
School of Materials Science, Materials Chemistry Area
◆Degrees
Doctor of Engineering from Kyoto University(2004) 京都大学
◆Professional Experience
2009 - 2010 : Kyoto University , Institute for Frontier Medical Sciences , 研究員
◆Specialties
Biomaterials, Biomedical engineering, Medical systems
◆Research Keywords
cryobiology, tissue engineering, gel, functional polymer, biomaterials, 幹細胞, 凍結保存, 両性高分子, 生体機能材料, iPS細胞, カルボキシル化ポリリジン, 凍害防止保存液, ε-ポリ-L-リジン(PLL), 氷の再結晶化抑制効果, ガラス化凍結保存
◆Research Interests
Functional polymeric biomaterials
The creation of functional polymers is a widely studied process for application in biomaterials and tissue engineering materials. Functional polymers have many applications with regard to biomaterials, such as hydrogels, bioabsorbable materials, and artificial bones. In this regard, not only bulky soft materials but also colloids, micelles, and even solutions can be studied as materials for controlling the functions of cells or tissues. Polyampholytes are polymers that have both positive and negative ions in 1 molecule. Our results revealed that several kinds of polyampholytes have a cryoprotective effect on cells in solution. This interesting phenomenon is a characteristic of polymers with high electron charge, especially polyampholytes. From the cryobiological viewpoint, cells are killed because of damage caused by intracellular crystallization of water during freezing. Therefore, we usually add some membrane-permeable chemicals such as dimethyl sulfoxide to cryopreserve cells. However, the phenomenon that non-membrane-penetrating polymers such as polyampholytes can reduce the damage that occurs during freezing cannot be explained on the basis of current knowledge in cryobiology. We will investigate and develop membrane-protective materials that can control cell functions by clarifying the mechanisms underlying such effects. Polyampholytes can change their conformation by controlling the polyion complex and thus exhibit various interesting physicochemical properties. We will try to develop novel functional materials by investigating the interactions between living systems and these polymers and by using the physicochemical properties of the polymers. We also perform basic and applied research on materials well-matched to living systems; this research is aimed toward the regeneration of functions in tissue engineering. In particular, we are trying to develop a novel cell culture scaffold, polymeric nano-carriers for drug delivery systems and articular cartilage by using hydrogels with high mechanical properties. The research performed in our laboratory is aimed toward the fusion of chemistry and biology through polymer chemistry and toward the development of materials that can control living systems. 備考

■Publications

◆Published Papers
Controlling the degradation of cellulose scaffolds with Malaprade oxidation for tissue engineering.
Wichchulada Chimpibul, Tadashi Nakaji-Hirabayashi, Xida Yuan, Kazuaki Matsumura
Journal of materials chemistry. B, -, 2020
Molecular design of polyampholytes for vitrification-induced preservation of three-dimensional cell constructs without using liquid nitrogen.
Kazuaki Matsumura, Sho Hatakeyama, Toshiaki Naka, Hiroshi Ueda, Robin Rajan, Daisuke Tanaka, Suong-Hyu Hyon
Biomacromolecules, -, 2020
Development of an efficient vitrification method for chondrocyte sheets for clinical application.
Asuka Hayashi, Miki Maehara, Ayuko Uchikura, Hitomi Matsunari, Kazuaki Matsumura, Suong-Hyu Hyon, Masato Sato, Hiroshi Nagashima
Regenerative therapy, 14, 215-221, 2020
Novel anti-biofouling and drug releasing materials for contact lenses.
Hiroaki Ogawa, Tadashi Nakaji-Hirabayashi, Kazuaki Matsumura, Chiaki Yoshikawa, Hiromi Kitano, Yoshiyuki Saruwatari
Colloids and surfaces. B, Biointerfaces, 189, 110859-110859, 2020
Cryoprotective Effect of Carboxylated Poly-L-lysine on the Chrysanthemum Shoot Tips
Daisuke Tanaka, Yoshinori Sakuma, Kazuaki Matsumura
Accepted, -, 2020
◆Misc
磁性-プラズモンハイブリッドナノ粒子を用いたオートファゴソームの磁気分離
高橋 麻里, プリヤンク・モハン, 向井 康治朗, 武田 裕一, 松本 多圭夫, 松村 和明, 高倉 正博, 新井 洋由, 田口 友彦, 前之園 信也
日本バイオマテリアル学会大会予稿集, 39回, 209-209, 2017
プロダクトマテリアルの質感創出の試行
永井由佳里, 宮田一乘, 日高昇平, 松村和明, 長尾祐樹
日本認知科学会大会発表論文集(CD-ROM), 34th, 896‐898-, 2017
Cryoprotective effect of carboxylated poly-L-lysine on the nematode Caenorhabditis elegans
Masakazu Hayashi, Norio Murase, Kazuaki Matsumura
Refrigeration Science and Technology, 4517-4520, 2015
Degradation control of cellulose scaffold by Malaprade oxidation
Wichchulada Konkumnerd, Suong-Hyu Hyon, Kazuaki Matsumura
Journal of Fluid Mechanics, 1621, -, 2014
To see a friend from different field is a joy
Kazuaki Matsumura
Kobunshi, 63, 39-40, 2014
◆Books
ACS Symposium SeriesVol. 1350, Polymers in Therapeutic Delivery. Design of Stimuli-Responsive Polyampholytes and Their Transformation into Micro-Hydrogels for Drug Delivery
共著, American Chemical Society, 2020
Development and Application of Cryoprotectants (Chapter 18), In Survival Strategies in Extreme Cold and Desiccation. Eds Mari Iwaya-Inoue, Minoru Sakurai, Matsuo Uemura
339-354, Springer, 2018
分解性多糖類ハイドロゲルの医療応用、医療用バイオマテリアルの研究開発
147-156, シーエムシー出版, 2017
Medical Application ofPolyampholytes. In Biopolymers for Medical Applications
pp 164-181, CRC Press, 2016
緑茶カテキンの再生医療への応用, ポリフェノール:機能性成分研究開発の最新動向, 監修:波多野力、下田博司
共著, シーエムシー出版、pp240-247. 2016, 2016
◆Conference Activities & Talks
THERMORESPONSIVE DEGRADATION CONTROL OF POLYSACCHARIDES FOR DRUG DELIVERY
107th Indian Science Congress, 2020
Vitrification of spheroids by using polyampholytes without liquid nitrogen
TEMRIS-AP+ABMC7, 2019
細胞の時間を止める-凍結保護を可能とする高分子
第68回高分子討論会, 2019
150℃におけるスフェロイドのガラス化保存
第64回低温生物工学会, 2019
Intracellular delivery of biomolecules via freeze concentration using polyampholyte nanocarriers
ACS National Meeting & Exposition, 2019

■Teaching Experience

Materials Design(E), Evaluation of Functions of Materials(E), Polymer Chemistry II, Introduction of Chemistry, 材料設計特論(E), 機能評価特論(E), ナノ分子解析論, 分子設計特論, 高分子化学特論II, 材料化学概論

■Contributions to  Society

◆Academic Society Affiliations
American Chemical Society, JAPANESE SOCIETY FOR CRYOBIOLOGY AND CRYOTECHNOLOGY, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, THE JAPANESE SOCIETY FOR BIOMATERIALS, THE SOCIETY OF POLYMER SCIENCE, JAPAN, THE CHEMICAL SOCIETY OF JAPAN
◆Academic Contribution
International Workshop on Functional Polymer Science and Interface 2013 , Kazuaki Matsumura, Associate professor, JAIST , 2013 , JAIST
理事 , 低温生物工学会
低温生物工学会誌編集委員 , 低温生物工学会

■Academic  Awards

・ 科学奨励賞 , 松村 和明 , 低温生物工学会 , 2015
・ 学長賞(研究活動賞) , 松村 和明 , 北陸先端科学技術大学院大学 , 2015
・ 科学奨励賞 , 松村 和明 , 日本バイオマテリアル学会 , 2014