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MATSUMURA, Kazuaki Professor, Director of Research Center for Exponential Biomedical DX, Director of Materials Chemistry Frontiers Research Area
Materials Science, Materials Chemistry Frontiers, Research Center for Biological Function and Sensory Information, Research Center for Exponential Biomedical DX (Excellent Core)
◆Degrees
Doctor of Engineering from Kyoto University(2004) Kyoto University
◆Professional Experience
2020 - : Japan Advanced Institute of Science and Technology , 教授
2011 - 2020 : Japan Advanced Institute of Science and Technology , 准教授
2009 - 2010 : Kyoto University , Institute for Frontier Medical Sciences , 研究員
◆Specialties
Biomaterials, Biomedical engineering, Medical systems
◆Research Keywords
cryobiology, tissue engineering, gel, functional polymer, biomaterials, 幹細胞, 凍結保存, 両性高分子, 生体機能材料, iPS細胞, カルボキシル化ポリリジン, 凍害防止保存液, ε-ポリ-L-リジン(PLL), 氷の再結晶化抑制効果, ガラス化凍結保存
◆Research Interests
Functional polymeric biomaterials
The creation of functional polymers is a widely studied process for application in biomaterials and tissue engineering materials. Functional polymers have many applications with regard to biomaterials, such as hydrogels, bioabsorbable materials, and artificial bones. In this regard, not only bulky soft materials but also colloids, micelles, and even solutions can be studied as materials for controlling the functions of cells or tissues. Polyampholytes are polymers that have both positive and negative ions in 1 molecule. Our results revealed that several kinds of polyampholytes have a cryoprotective effect on cells in solution. This interesting phenomenon is a characteristic of polymers with high electron charge, especially polyampholytes. From the cryobiological viewpoint, cells are killed because of damage caused by intracellular crystallization of water during freezing. Therefore, we usually add some membrane-permeable chemicals such as dimethyl sulfoxide to cryopreserve cells. However, the phenomenon that non-membrane-penetrating polymers such as polyampholytes can reduce the damage that occurs during freezing cannot be explained on the basis of current knowledge in cryobiology. We will investigate and develop membrane-protective materials that can control cell functions by clarifying the mechanisms underlying such effects. Polyampholytes can change their conformation by controlling the polyion complex and thus exhibit various interesting physicochemical properties. We will try to develop novel functional materials by investigating the interactions between living systems and these polymers and by using the physicochemical properties of the polymers. We also perform basic and applied research on materials well-matched to living systems; this research is aimed toward the regeneration of functions in tissue engineering. In particular, we are trying to develop a novel cell culture scaffold, polymeric nano-carriers for drug delivery systems and articular cartilage by using hydrogels with high mechanical properties. The research performed in our laboratory is aimed toward the fusion of chemistry and biology through polymer chemistry and toward the development of materials that can control living systems. 備考_alt

■Publications

◆Published Papers
Thermoresponsive behavior of dual hydrophilic diblock copolymers prepared via organotellurium-mediated living radical polymerization
Misato Hayashi, Rintaro Takahashi, Thi Ngan Vu, Kazuaki Matsumura, Shigeru Yamago, Shin-ichi Yusa
Polymer Journal, -, 2024
Molecular mechanism of protein aggregation inhibition with sulfobetaine polymers and their hydrophobic derivatives
Robin Rajan, Tadaomi Furuta, Dandan Zhao, Kazuaki Matsumura
Cell Reports Physical Science, 102012-102012, 2024
Design of Highly Selective Zn-Coordinated Polyampholyte for Cancer Treatment and Inhibition of Tumor Metastasis.
Nishant Kumar, Tadashi Nakaji-Hirabayashi, Moe Kato, Kazuaki Matsumura, Robin Rajan
Biomacromolecules, 25, 3, 1481-1490, 2024
Cryopreservation of rat embryos at all developmental stages by small-volume vitrification procedure and rapid warming in cryotubes.
Shinsuke Seki, Toshiaki Kawabe, Wataru Yamazaki, Kazuaki Matsumura, Takanori Oikawa, Takahiro Obata, Misako Higashiya, Megumi Yano, Tomoo Eto
Scientific reports, 13, 1, 20903-20903, 2023
Optogenetic Calcium Ion Influx in Myoblasts and Myotubes by Near-Infrared Light Using Upconversion Nanoparticles
Daisuke Maemura, The Son Le, Mari Takahashi, Kazuaki Matsumura, Shinya Maenosono
ACS Applied Materials & Interfaces, -, 2023
◆Misc
Development of 3D culture system using concentrated polymer brush-modified cellulose nanofibers
YUAN Xida, NONSUWAN Punnida, 榊原圭太, 松村和明, 吉川千晶
日本バイオマテリアル学会大会予稿集(Web), 43rd, -, 2021
凍結過程におけるポリマーと塩の相互作用
山崎椋太, RAJAN Robin, 林文晶, 長嶋敏雄, 松村和明
低温生物工学会セミナー及び年会講演要旨集, 66th, -, 2021
凍結保護物質の化学
松村和明, RAJAN Robin
低温生物工学会セミナー及び年会講演要旨集, 66th, -, 2021
Successful vitrification of rat embryos using a carboxylated ε-poly-L-lysine
鴨下 真紀, 中野 成実, 藤原 克祥, 須山 あゆみ, 松村 和明, 玄 丞烋, 伊藤 潤哉, 柏崎 直巳
Journal of mammalian ova research, 37, 1, 31-35, 2020
カルボキシル基導入ポリリジンおよびpolyvinyl alcoholを用いたC57BL/6Jマウス前核期胚のガラス化保存法の改良
石井緑, 鴨下真紀, 松村和明, 玄丞烋, 伊藤潤哉, 伊藤潤哉, 柏崎直巳, 柏崎直巳
日本畜産学会大会講演要旨, 124th, -, 2018
◆Books
ACS Symposium SeriesVol. 1350, Polymers in Therapeutic Delivery. Design of Stimuli-Responsive Polyampholytes and Their Transformation into Micro-Hydrogels for Drug Delivery
共著, American Chemical Society, 2020
Development and Application of Cryoprotectants (Chapter 18), In Survival Strategies in Extreme Cold and Desiccation. Eds Mari Iwaya-Inoue, Minoru Sakurai, Matsuo Uemura
339-354, Springer, 2018
分解性多糖類ハイドロゲルの医療応用、医療用バイオマテリアルの研究開発
147-156, シーエムシー出版, 2017
Medical Application ofPolyampholytes. In Biopolymers for Medical Applications
pp 164-181, CRC Press, 2016
緑茶カテキンの再生医療への応用, ポリフェノール:機能性成分研究開発の最新動向, 監修：波多野力、下田博司
共著, シーエムシー出版、pp240-247. 2016, 2016
◆Conference Activities & Talks
Dehydration controlling mechanism of cryoprotection of membrane non-penetrating polyampholytes cryoprotectants by solid-state NMR
World Biomaterials Congress 2020, 2020
Mechanism of cryoprotection by polyampholytes and their applications
Cryopreservation Conference 2020, 2020
pH dependent multi-drug delivery system by polyampholytic hydrogel
第69回高分子討論会, 2020
THERMORESPONSIVE DEGRADATION CONTROL OF POLYSACCHARIDES FOR DRUG DELIVERY
107th Indian Science Congress, 2020
Vitrification of spheroids by using polyampholytes without liquid nitrogen
TEMRIS-AP+ABMC7, 2019

■Teaching Experience

Materials Design(E), Evaluation of Functions of Materials(E), Polymer Chemistry II, Introduction of Chemistry, 材料設計特論(E), 機能評価特論(E), ナノ分子解析論, 分子設計特論, 高分子化学特論II, 材料化学概論

■Contributions to  Society

◆Academic Society Affiliations
American Chemical Society, JAPANESE SOCIETY FOR CRYOBIOLOGY AND CRYOTECHNOLOGY, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, THE JAPANESE SOCIETY FOR BIOMATERIALS, THE SOCIETY OF POLYMER SCIENCE, JAPAN, THE CHEMICAL SOCIETY OF JAPAN
◆Academic Contribution
International Workshop on Functional Polymer Science and Interface 2013 , Kazuaki Matsumura, Associate professor, JAIST , 2013 , JAIST
理事 , 低温生物工学会
評議員 , 日本バイオマテリアル学会

■Academic  Awards

・ SPSJ Mitsubishi Chemical Award , 高分子学会 , 2021
・ 科学奨励賞 , 松村 和明 , 低温生物工学会 , 2015
・ 学長賞（研究活動賞） , 松村 和明 , 北陸先端科学技術大学院大学 , 2015