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塚原 俊文 (TSUKAHARA, Toshifumi)副学長, 先端科学技術研究科長, 教授, 融合科学系長
融合科学系, マテリアルサイエンス系, 生命機能工学領域

発表論文

67件
Development of a Single Construct System for Site-Directed RNA Editing Using MS2-ADAR
Tetsuto Tohama, Matomo Sakari, Toshifumi Tsukahara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 14, -, 2020
The anticancer activity of two glycosides from the leaves ofLeea aequataL.
Abdul Rahim, Md Golam Mostofa, Md Golam Sadik, Md Aziz Abdur Rahman, Md Ibrahim Khalil, Toshifumi Tsukahara, Kyoko Nakagawa-Goto, A. H. M. Khurshid Alam
NATURAL PRODUCT RESEARCH, 1-5, 2020
The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB
Sasithorn Wanna-udom, Minoru Terashima, Hanbing Lyu, Akihiko Ishimura, Takahisa Takino, Matomo Sakari, Toshifumi Tsukahara, Takeshi Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 524, 1, 150-155, 2020
Artificial RNA Editing with ADAR for Gene Therapy.
Sonali Bhakta, Toshifumi Tsukahara
Current gene therapy, 20, 1, 44-54, 2020
Analysis of Tissue-specific RNA Editing Events of Genes Involved in RNA Editing in Arabidopsis thaliana
Umme Qulsum, Md. Thoufic Anam Azad, Toshifumi Tsukahara
JOURNAL OF PLANT BIOLOGY, 62, 5, 351-358, 2019
Single nucleotide recognition using a probes-on-carrier DNA chip
Saifullah, Satoshi Fuke, Hiroshi Nagasawa, Toshifumi Tsukahara
BIOTECHNIQUES, 66, 2, 73-78, 2019
Comparative Activity of Adenosine Deaminase Acting on RNA (ADARs) Isoforms for Correction of Genetic Code in Gene Therapy.
Md Thoufic A Azad, Umme Qulsum, Toshifumi Tsukahara
Current gene therapy, 19, 1, 31-39, 2019
Genetic code restoration by artificial RNA editing of Ochre stop codon with ADAR1 deaminase.
Sonali Bhakta, Md Thoufic Anam Azad, Toshifumi Tsukahara
Protein engineering, design & selection : PEDS, 31, 12, 471-478, 2018
Tissue-specific alternative splicing of pentatricopeptide repeat (PPR) family genes in Arabidopsis thaliana
Umme Qulsum, Toshifumi Tsukahara
BIOSCIENCE TRENDS, 12, 6, 569-579, 2018
Genotyping of single nucleotide polymorphisms using the SNP-RFLP method
Saifullah, Toshifumi Tsukahara
BIOSCIENCE TRENDS, 12, 3, 240-246, 2018
C-to-U editing and site-directed RNA editing for the correction of genetic mutations.
Luyen Thi Vu, Toshifumi Tsukahara
Bioscience trends, 11, 3, 243-253, 2017
Neuron-specific splicing.
Nor Hakimah Ab Hakim, Burhanuddin Yeop Majlis, Hitoshi Suzuki, Toshifumi Tsukahara
Bioscience trends, 11, 1, 16-22, 2017
Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot
Hitoshi Suzuki, Yoshitsugu Aoki, Toshiki Kameyama, Takashi Saito, Satoru Masuda, Jun Tanihata, Tetsuya Nagata, Akila Mayeda, Shin'ichi Takeda, Toshifumi Tsukahara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17, 10, -, 2016
Chemical RNA Editing for Genetic Restoration: The Relationship between the Structure and Deamination Efficiency of Carboxyvinyldeoxyuridine Oligodeoxynucleotides.
Luyen Thi Vu, Thanh Thi Kim Nguyen, Azad Anam Md Thoufic, Hitoshi Suzuki, Toshifumi Tsukahara
Chemical biology & drug design, 87, 4, 583-93, 2016
Changing Blue Fluorescent Protein to Green Fluorescent Protein Using Chemical RNA Editing as a Novel Strategy in Genetic Restoration
Luyen T. Vu, Thanh T. K. Nguyen, Shafiul Alam, Takashi Sakamoto, Kenzo Fujimoto, Hitoshi Suzuki, Toshifumi Tsukahara
CHEMICAL BIOLOGY & DRUG DESIGN, 86, 5, 1242-1252, 2015
Computational extraction of a neural molecular network through alternative splicing.
Shafiul Alam, Huong Thi Thanh Phan, Mio Okazaki, Masahiro Takagi, Kozo Kawahara, Toshifumi Tsukahara, Hitoshi Suzuki
BMC research notes, 7, 934-934, 2014
Alternative splicing regulation of APP exon 7 by RBFox proteins.
Shafiul Alam, Hitoshi Suzuki, Toshifumi Tsukahara
Neurochemistry international, 78, 7-17, 2014
A View of Pre-mRNA Splicing from RNase R Resistant RNAs
Hitoshi Suzuki, Toshifumi Tsukahara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 15, 6, 9331-9342, 2014
Nested introns in an intron: evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA.
Hitoshi Suzuki, Toshiki Kameyama, Kenji Ohe, Toshifumi Tsukahara, Akila Mayeda
FEBS letters, 587, 6, 555-61, 2013
Nested introns in an intron: Evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA
Hitoshi Suzuki, Toshiki Kameyama, Kenji Ohe, Toshifumi Tsukahara, Akila Mayeda
FEBS LETTERS, 587, 6, 555-561, 2013
Alternative splicing produces structural and functional changes in CUGBP2
Hitoshi Suzuki, Makoto Takeuchi, Ayumu Sugiyama, A. H. M. Khurshid Alam, Luyen Thi Vu, Yoshiharu Sekiyama, Hieu Chi Dam, Shin-ya Ohki, Toshifumi Tsukahara
BMC BIOCHEMISTRY, 13, 6-6, 2012
Functional Gene Expression Analysis of Tissue-Specific Isoforms of Mef2c
Yoshiharu Sekiyama, Hitoshi Suzuki, Toshifumi Tsukahara
CELLULAR AND MOLECULAR NEUROBIOLOGY, 32, 1, 129-139, 2012
Comprehensive Analysis of Alternative Splicing and Functionality in Neuronal Differentiation of P19 Cells
Hitoshi Suzuki, Ken Osaki, Kaori Sano, A. H. M. Khurshid Alam, Yuichiro Nakamura, Yasuhito Ishigaki, Kozo Kawahara, Toshifumi Tsukahara
PLOS ONE, 6, 2, e-, 2011
Possibility of genetic restoration for a disease treatment
Toshifumi Tsukahara, Yu Ooka, Shafiul Alam, Hitoshi Suzuki, Kenzo Fujimoto
2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011, -, 2011
Retinoic acid treatment and cell aggregation independently regulate alternative splicing in P19 cells during neural differentiation
A. H. M. Khurshid Alam, Hitoshi Suzuki, Toshifumi Tsukahara
CELL BIOLOGY INTERNATIONAL, 34, 6, 631-643, 2010
Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cells
Nor Hakimah Ab Hakim, Toshiki Kounishi, A. H. M. Khurshid Alam, Toshifumi Tsukahara, Hitoshi Suzuki
GENES TO CELLS, 15, 3, 255-267, 2010
Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCMand EIS
Truong Thi, Ngoc Lien, Tran Dai Lam, Vu Thi Hong An, Tran Vinh Hoang, Duong Tuan Quang, Dinh Quang Khieu, Toshifumi Tsukahara, Young Hoon Lee, Jong Seung Kim
Tlanta, 80, 3, 1164-1169, 2010
Expression analysis of Fgf8a & Fgf8b in early stage of P19 cells during neural differentiation
A. H. M. Khurshid Alam, Hitoshi Suzuki, Toshifumi Tsukahara
CELL BIOLOGY INTERNATIONAL, 33, 9, 1032-1037, 2009
Localization of c- mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba
Hitoshi Suzuki, Toshifumi Tsukahara, Kunio Inoue
BIOSCIENCE TRENDS, 3, 3, 96-104, 2009
'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups
Akihiro Ohkubo, Rintaro Kasuya, Kazushi Sakamoto, Kenichi Miyata, Haruhiko Taguchi, Hiroshi Nagasawa, Toshifumi Tsukahara, Takuma Watanobe, Yoshiyuki Maki, Kohji Seio, Mitsuo Sekine
NUCLEIC ACIDS RESEARCH, 36, 6, 1952-1964, 2008
Protected DNA probes (PDP): A new strategy for gene detection
Akihiro Ohkubo, Itaru Okamoto, Rintaro Kasuya, Kazushi Sakamoto, Takeshi Sasami, Yoko Odawara, Yoshiaki Masaki, Toshiyuki Sakaue, Hiroshi Nagasawa, Toshifumi Tsukahara, Kohji Seio, Mitsuo Sekine
CHEMISTRY OF NUCLEIC ACID COMPONENTS, 10, 94-102, 2008
An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis
Akihiro Ohkubo, Kunihiko Tanaka, Haruhiko Taguchi, Kohji Seio, Hiroshi Nagasawa, Toshifurni Tsukahara, Mitsuo Sekine
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17, 21, 5969-5973, 2007
A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis
Akihiro Ohkubo, Haruhiko Taguchi, Kohji Seio, Hiroshi Nagasawa, Toshifumi Tsukahara, Mitsuo Sekine
TETRAHEDRON LETTERS, 48, 29, 5147-5150, 2007
JAIST International Symposium on Nanotechnology 2006 (NT2006)
Hideki Matsumura, Toshifumi Tsukahara
Science and Technology of Advanced Materials, 8, 4, 271-272, 2007
Upregulations of Gata4 and oxytocin receptor are important in cardiomyocyte differentiation processes of P19CL6 cells
Shizuka Uchida, Satoshi Fuke, Toshifumi Tsukahara
JOURNAL OF CELLULAR BIOCHEMISTRY, 100, 3, 629-641, 2007
Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system
Satoshi Fuke, Natsumi Minami, Hiroki Kokubo, Ayumu Yoshikawa, Hiroshi Yasumatsu, Noboru Sasagawa, Yumiko Saga, Toshifumi Tsukahara, Shoichi Ishiura
JOURNAL OF NEUROSCIENCE RESEARCH, 84, 7, 1555-1563, 2006
Aberrant neuromuscular junctions and delayed terminal muscle fiber maturation in alpha-dystroglycanopathies
M Taniguchi, H Kurahashi, S Noguchi, T Fukudome, T Okinaga, T Tsukahara, Y Tajima, K Ozono, Nishino, I, Nonaka, I, T Toda
HUMAN MOLECULAR GENETICS, 15, 8, 1279-1289, 2006
Expression profiling of muscles from Fukuyama-type congenital muscular dystrophy and laminin-α2 deficient congenital muscular dystrophy; is congenital muscular dystrophy a primary fibrotic disease?
Mariko Taniguchi, Hiroki Kurahashi, Satoru Noguchi, Jun Sese, Takeshi Okinaga, Toshifumi Tsukahara, Pascale Guicheney, Keiichi Ozono, Ichizo Nishino, Shinichi Morishita, Tatsushi Toda
Biochemical and Biophysical Research Communications, 342, 2, 489-502, 2006
Prediction of tertiary structure of NSSRsユ RNA recognition motif and the RNA binding activity.
Kazuo Fushimi, Shizuka Uchida, Ryousuke Matsushita, Toshifumi Tsukahara
Sci Techno Adv Materials, 6, 5, 475-483, 2005
NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs
K Fushimi, N Osumi, T Tsukahara
GENES TO CELLS, 10, 6, 531-541, 2005
Transcriptional study of cardiac differentiation mechanism of DMSO
Shizuka Uchida, Takashi Tatsuhama, Toshifumi Tsukahara
CELL STRUCTURE AND FUNCTION, 30, 84-84, 2005
Probe-on-carriers for oligonucleotide microarrays (DNA chips)
T Tsukahara, H Nagasawa
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 5, 3, 359-362, 2004
独自に開発したヒト骨格筋用cDNAマイクロアレイによる遺伝子発現解析
西野 一三, 野口 悟, 塚原 俊文, 藤田 雅子, 黒川 留美, 戸田 達史, 辻本 敦美
臨床神経学, 43, 12, 937-937, 2003
Expression of ARPP-16/19 in rat denervated skeletal muscle
A Yoshikawa, H Mitsuhashi, N Sasagawa, T Tsukahara, Y Hayashi, Nishino, I, Y Goto, S Ishiura
JOURNAL OF BIOCHEMISTRY, 134, 1, 57-61, 2003
遺伝性筋疾患に対する分子治療の基盤研究 ヒト筋マイクロアレイの開発とそれを用いた筋疾患の分子病態の解明
塚原 俊文, 野口 悟, 西野 一三, 辻本 敦美
厚生労働省精神・神経疾患研究委託費研究報告集, 平成14年度, 116-116, 2003
cDNA microarray analysis of individual Duchenne muscular dystrophy patients
S Noguchi, T Tsukahara, M Fujita, R Kurokawa, M Tachikawa, T Toda, A Tsujimoto, K Arahata, Nishino, I
HUMAN MOLECULAR GENETICS, 12, 6, 595-600, 2003
A comparative gene expression analysis of Emery-Dreifuss muscular dystrophy using a cDNA microarray.
Toshifumi Tsukahara, Kiichi Arahata
Methods in molecular biology (Clifton, N.J.), 217, 253-262, 2003
筋ジストロフィーの表現型・遺伝型の分子医学的研究
荒畑 喜一, 林 由起子, 塚原 俊文, 後藤 加奈子, 小川 恵, 田川 一彦, 松田 知栄, 川辺 清一, 松村 剛, 山中 岳, 野口 悟, 計良 陽子, 平瀬 正樹, 辻本 敦美, 森下 真一, 瀬々 潤, 青木 正志, Brown,Jr. Robert H., 石原 傳幸, 村山 久美子, 南 成祐, 西野 一三, 埜中 征哉
厚生労働省精神・神経疾患研究委託費研究報告書 筋ジストロフィー及び関連疾患の臨床病態解明と治療法開発に関する研究, 平成11〜13年度, 22-24, 2002
Increased expression level of the splicing variant of SIP1 in motor neuron diseases
Wulin Aerbajinai, Tadayuki Ishihara, Kiichi Arahata, Toshifumi Tsukahara
International Journal of Biochemistry and Cell Biology, 34, 6, 699-707, 2002
The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression
Yeon-Jeong Kim, Satoru Noguchi, Yukiko K. Hayashi, Toshifumi Tsukahara, Takao Shimizu, Kiichi Arahata
Human Molecular Genetics, 10, 11, 1129-1139, 2001
Nuclear accumulation of expanded PABP2 gene product in oculopharyngeal muscular dystrophy
Eiichiro Uyama, Toshifumi Tsukahara, Kanako Goto, Yoshihiro Kurano, Megumu Ogawa, Yeon-Jeong Kim, Makoto Uchino, Kiichi Arahata
Muscle and Nerve, 23, 10, 1549-1554, 2000
Changes in pre-mRNA splicing factors during neural differentiation in P19 embryonal carcinoma cells
Ayako Shinozaki, Kiichi Arahata, Toshifumi Tsukahara
International Journal of Biochemistry and Cell Biology, 31, 11, 1279-1287, 1999
Apoptosis in favourable neuroblastomas is not dependent on Fas (CD95/APO-1) expression but on activated caspase 3 (CPP32)
Hirotaka Koizumi, Ikuo Ohkawa, Toshifumi Tsukahara, Takashi Momoi, Koonosuke Nakada, Toshiyuki Uchikoshi
Journal of Pathology, 189, 3, 410-415, 1999
Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones
Masaaki Komatsu, Eiki Kominami, Kiichi Arahata, Toshifumi Tsukahara
Genes to Cells, 4, 10, 593-606, 1999
RA70 is a src kinase-associated protein expressed ubiquitously
Yoriko Kouroku, Akiko Soyama, Eriko Fujita, Koko Urase, Toshifumi Tsukahara, Takashi Momoi
Biochemical and Biophysical Research Communications, 252, 3, 738-742, 1998
Presence of emerinopathy in cases of rigid spine syndrome
Shinichiro Kubo, Toshifumi Tsukahara, Masakazu Takemitsu, Kim Bong Yoon, Hiroya Utsumi, Ikuya Nonaka, Kiichi Arahata
Neuromuscular Disorders, 8, 7, 502-507, 1998
Mutations in the integrin α7 gene cause congenital myopathy
Yukiko K. Hayashi, Fan-Li Chou, Eva Engvall, Megumu Ogawa, Chie Matsuda, Shinichi Hirabayashi, Kenji Yokochi, Barry L. Ziober, Randall H. Kramer, Stephen J. Kaufman, Eijiro Ozawa, Yu-Ichi Goto, Ikuya Nonaka, Toshifumi Tsukahara, Jian-Zhou Wang, Eric P. Hoffman, Kiichi Arahata
Nature Genetics, 19, 1, 94-97, 1998
Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas
Eriko Fujita, Yoriko Kouroku, Yasuko Miho, Toshifumi Tsukahara, Shouichi Ishiura, Takashi Momoi
Cell Death and Differentiation, 5, 4, 289-297, 1998
Involvement of Sonic hedgehog in the cell growth of LK-2 cells, human lung squamous carcinoma cells
Eriko Fujita, Yoriko Khoroku, Koko Urase, Toshifumi Tsukahara, Mariko Y. Momoi, Hiromichi Kumagai, Tamiko Takemura, Toshio Kuroki, Takashi Momoi
Biochemical and Biophysical Research Communications, 238, 2, 658-664, 1997
Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid
Takeshi Mukasa, Yoriko Khoroku, Toshifumi Tsukahara, Mariko Y. Momoi, Ichiroh Kimura, Takashi Momoi
Biochemical and Biophysical Research Communications, 232, 1, 192-197, 1997
49. Laminin in Animal Models for Muscular Dystrophy Defect of Laminin M in Skeletal and Cardiac Muscles and Peripheral Nerve of the Homozygous Dystrophic dy/dy Mice
Kiichi Arahata, Ritsuko Koga, Kanako Goto, Je Hveon Lee, Yuko Miyagoe, Toshifumi Tsukahara, Ikuya Nonaka, Tetsuya Matsuzaki, Hideo Sugita, Yukiko K. Hayashi, Hiroko Ishii, Man Woo
Proceedings of the Japan Academy, Series B, 69, 10, 259-264, 1993
Antiserum Against the Synthetic Polypeptide Fragment of Dystrophin Cross-Reacts with Myofibrillar C-Protein.
Masahito Yamaguchi, Shoichi Ishiura, Toshifumi Tsukahara, Kiichi Arahata, Hideo Sugita, Masahito Yamaguchi, Takahide Tsuchiya, Toru Tamiya, Takashi Obinata, Hiromi Takano-Ohmuro
Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 66, 1, 19-22, 1990
Negative Immunostaining of Duchenne Muscular Dystrophy (DMD) and mdx Muscle Surface Membrane with Antibody against Synthetic Peptide Fragment predicted from DMD cDNA
Hideo Sugita, Kiichi Arahata, Yoshihiro Suhara, Toshifumi Tsukahara, Shoichi Ishiura, Ikuya Nonaka, Eijiro Ozawa, Tsuneo Ishiguro, Chikahiko Eguchi
Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 64, 2, 37-39, 1988
Localization of BUT Serine Esterase is Distinct from that of Perforin in Cytotoxic T Lymphocyte
Hirotaka Koizumi, Toshifumi Tsukahara, Shoichi Ishiura, Hideo Sugita
Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 64, 6, 155-158, 1988
The “ATP-Dependent Protease” in Human Erythroleukemia (K562) Cells is Identical to a High-Molecular-Mass Protease, Ingensin
Toshifumi Tsukahara, Shoichi Ishiura, Hideo Sugita
Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 64, 3, 72-75, 1988